Mampilly Mathew O, Ravindran Nidhi, Parambil Mohamed Shajith, Nilesh Kumar, Jayagopalan Parvathi, Dhamali Debjit
Department of Oral and Maxillofacial Surgery and Dentistry, ESIC Medical College and PG Institute, Bengaluru, Karnataka, India.
Department of Dentistry, Sree Narayana Institute of Medical Sciences, Kochi, Kerala, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S989-S992. doi: 10.4103/jpbs.jpbs_380_21. Epub 2021 Nov 10.
Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases.
A total of 20 patients and 10 healthy individuals, aged 30-60 years, were chosen from the outpatient Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, Karnataka. The participants were grouped into three: Group 1: (10 healthy individuals), Group 2: (10 oral leukoplakia patients) and Group 3: (10 squamous cell carcinoma patients). Blood was chosen as the investigative medium. Ceruloplasmin was estimated by the diamine oxidase method. The technique of atomic absorption developed by Sir Alan Walsh in 1950 has become the preferred method of elemental analysis of selenium (atomic absorption spectrometer). Statistical analysis of the data obtained was done using one-way ANOVA test and the Turkey multiple comparisons test.
The intergroup comparison of ceruloplasmin shows that the mean value of Group I (Control) was 31.746 mg/dl, the mean value of Group II (leukoplakia) was 81.411 mg/dl, and the mean value of Group III (squamous cell carcinoma) was 90.7120 mg/dl. The intergroup comparison of selenium levels shows that the mean value of Group I (Control) was 119.937 (ng/ml), the mean value of Group II (leukoplakia) was 109.17 (ng/ml), and the mean value of Group III (squamous cell carcinoma) was 99.6230 (ng/ml).
Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma.
尽管进行了广泛的研究与开发，但口腔潜在恶性疾病（PMDs）和口腔癌仍然是一个严重问题。饮食和免疫已被确定为这些疾病中重要的可调节因素。
从卡纳塔克邦耶内波亚牙科学院和医院口腔颌面外科门诊选取了20例患者和10名年龄在30至60岁之间的健康个体。参与者被分为三组：第一组：（10名健康个体），第二组：（10名口腔白斑患者）和第三组：（10名鳞状细胞癌患者）。选取血液作为检测介质。采用二胺氧化酶法测定铜蓝蛋白。1950年由艾伦·沃尔什爵士开发的原子吸收技术已成为硒元素分析的首选方法（原子吸收光谱仪）。对所得数据进行统计分析时使用了单因素方差分析测试和土耳其多重比较测试。
铜蓝蛋白的组间比较显示，第一组（对照组）的平均值为31.746毫克/分升，第二组（白斑）的平均值为81.411毫克/分升，第三组（鳞状细胞癌）的平均值为90.7120毫克/分升。硒水平的组间比较显示，第一组（对照组）的平均值为119.937（纳克/毫升），第二组（白斑）的平均值为109.17（纳克/毫升），第三组（鳞状细胞癌）的平均值为99.6230（纳克/毫升）。
抗氧化剂是抵御自由基对细胞损伤的重要防御系统。血清中的铜蓝蛋白和硒水平可作为白斑和鳞状细胞癌的疾病标志物。
