Brahmachari Swagata, Vasuniya Vikram, Mukherjee Soma, Chaurasia Aditi
Departments of General Surgery, AIIMS, Bhopal, Madhya Pradesh, India.
Department of General Surgery, AIIMS, Bhopal, Madhya Pradesh, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1381-S1385. doi: 10.4103/jpbs.jpbs_219_21. Epub 2021 Nov 10.
Triple test was a breakthrough in the initial screening of breast cancer due to its high sensitivity, but it has few limitations. To overcome those limitations, we developed a novel quadruple score which included physical examination, ultrasound, mammography, and fine-needle aspiration cytology (FNAC).
The aim of this study was to test the sensitivity, specificity, negative predictive value (NPV), and positive predictive value of a novel quadruple score for the initial screening of breast cancer.
This retrospective study was conducted on 320 patients having breast lump to the Breast Cancer Outpatient Department of AIIMS, Bhopal. The physical examination findings, breast sonography findings, mammography, and FNAC findings were recorded in the set pro forma, these were later analyzed, and a cumulative scoring was done categorizing patients in the benign, dubious, and malignant category according to the QTS score. These findings were then validated and compared by histopathology.
Statistical results show a positive covariance σ suggesting the positive relation between them; also, the correlation coefficient was 0.9996 suggesting a strong linear correlation. On comparing the accuracy of all four variables as physical examination, USG, mammography and FNAC individually and QTS, the accuracy of QTS was highest i.e 99.44%.
QTS is accurate and reliable diagnostic approach for evaluation of breast lumps. By using the quadruple scoring system, management of palpable breast lump will become more streamlined, providing a platform for managing discordant results, which can be followed universally.
三联检查因其高敏感性，在乳腺癌的初始筛查中是一项突破，但它也有一些局限性。为了克服这些局限性，我们开发了一种新的四重评分系统，该系统包括体格检查、超声、乳腺钼靶和细针穿刺细胞学检查（FNAC）。
本研究的目的是测试一种用于乳腺癌初始筛查的新型四重评分系统的敏感性、特异性、阴性预测值（NPV）和阳性预测值。
本回顾性研究对320例前往博帕尔全印医学科学研究所乳腺癌门诊的乳腺肿块患者进行。将体格检查结果、乳腺超声检查结果、乳腺钼靶检查结果和FNAC检查结果记录在规定的表格中，随后进行分析，并根据四重评分系统（QTS）对患者进行累积评分，将其分为良性、可疑和恶性类别。然后通过组织病理学对这些结果进行验证和比较。
统计结果显示正协方差σ，表明它们之间存在正相关关系；此外，相关系数为0.9996，表明存在强线性相关。在单独比较体格检查、超声、乳腺钼靶和FNAC这四个变量以及QTS的准确性时，QTS的准确性最高，即99.44%。
QTS是评估乳腺肿块准确且可靠的诊断方法。通过使用四重评分系统，可触及乳腺肿块的管理将变得更加简化，为处理不一致的结果提供一个平台，该平台可被广泛应用。
