Alanazi Fehaid
Department of Medicine, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1583-S1587. doi: 10.4103/jpbs.jpbs_300_21. Epub 2021 Nov 10.
Rheumatoid arthritis (RA) is a chronic, debilitating condition that has a significant effect on the lives of patients, their families, and society at large.
The aim is to determine the clinical profile and any comorbidities associated with RA patients in the Sudair region of Saudi Arabia.
Sixty patients were included in this cross-sectional observational study, both newly or already diagnosed with RA, fulfilling the 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for RA. They were followed up in the rheumatology clinic in King Khalid Majmaah Hospital in the Majmaah province from January 2017 to December 2020.
The subjects' mean age was 47.87 ± 11.55 years, 52 female and 8 male (female-to-male ratio 6.5:1). About 23.3% of patients with RA had positive family history. The main comorbidities and associated diseases were hypertension (18.3%) and hypothyroidism (15%). The most frequently involved joints were the wrist, metacarpophalangeal, proximal interphalangeal, elbow, and knee joints. Subjects were positive in 66.7% for rheumatoid factor and 78.3% for anti-cyclic citrullinated peptide. Both markers were positive in 60% of the patients.
Approximately one-quarter of the studied group had a family history of RA. Hypertension followed by hypothyroidism was the most common comorbidities reported in our study.
类风湿关节炎（RA）是一种慢性、使人衰弱的疾病，对患者及其家庭以及整个社会的生活都有重大影响。
目的是确定沙特阿拉伯苏代尔地区类风湿关节炎患者的临床特征以及任何合并症。
本横断面观察性研究纳入了60例患者，这些患者均为新诊断或已确诊的类风湿关节炎患者，符合2010年美国风湿病学会/欧洲抗风湿病联盟类风湿关节炎分类标准。他们于2017年1月至2020年12月在马吉马省哈立德国王马吉马医院的风湿病门诊接受随访。
受试者的平均年龄为47.87±11.55岁，女性52例，男性8例（女男比例为6.5:1）。约23.3%的类风湿关节炎患者有家族史阳性。主要合并症及相关疾病为高血压（18.3%）和甲状腺功能减退（15%）。最常受累的关节是腕关节、掌指关节、近端指间关节、肘关节和膝关节。类风湿因子阳性率为66.7%，抗环瓜氨酸肽阳性率为78.3%。两种标志物均阳性的患者占60%。
研究组中约四分之一的患者有类风湿关节炎家族史。高血压其次是甲状腺功能减退是我们研究中报告的最常见合并症。
