Attar Suzan M
Department of Internal Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2015 Jun;36(6):685-91. doi: 10.15537/smj.2015.6.10557.
To determine the prevalence of hyperlipidemia in patients from Saudi Arabia with rheumatoid arthritis (RA), and to investigate its relationship with C-reactive protein level and disease activity.
A cross-sectional 3-year study was conducted on RA patients at King Abdulaziz University Hospital, Saudi Arabia between January 2011 and December 2013. Lipid profiles were determined following 12-hour overnight fasting, and the association of lipid profiles with C-reactive protein (CRP) levels and disease activity was determined.
This study involved a total of 180 RA patients (mean age: 40.49±12.19 years). These subjects displayed a high prevalence of elevated total cholesterol (55.1%), and low-density lipoprotein cholesterol (51.2%). Notably, we detected a significant association between increased total cholesterol and high CRP levels (p=0.002). Moreover, we observed a positive correlation between total cholesterol and disease activity, as measured using the 28-Joint Disease Activity Score index (r=0.23, p=0.036).
Hyperlipidemia is common among RA patients and is significantly associated with CRP levels and disease activity. Our findings emphasize the need to raise awareness among healthcare professionals regarding the development of hyperlipidemia when RA is active.
确定沙特阿拉伯类风湿关节炎（RA）患者中高脂血症的患病率，并研究其与C反应蛋白水平和疾病活动度的关系。
2011年1月至2013年12月期间，在沙特阿拉伯阿卜杜勒阿齐兹国王大学医院对RA患者进行了一项为期3年的横断面研究。在禁食12小时过夜后测定血脂谱，并确定血脂谱与C反应蛋白（CRP）水平和疾病活动度的关联。
本研究共纳入180例RA患者（平均年龄：40.49±12.19岁）。这些受试者总胆固醇升高（55.1%）和低密度脂蛋白胆固醇升高（51.2%）的患病率较高。值得注意的是，我们检测到总胆固醇升高与高CRP水平之间存在显著关联（p=0.002）。此外，我们观察到总胆固醇与使用28关节疾病活动评分指数测量的疾病活动度之间呈正相关（r=0.23，p=0.036）。
高脂血症在RA患者中很常见，并且与CRP水平和疾病活动度显著相关。我们的研究结果强调，医疗保健专业人员需要提高对RA活动时高脂血症发生情况的认识。
