Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, USA.
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
J Gerontol A Biol Sci Med Sci. 2022 Mar 3;77(3):471-476. doi: 10.1093/gerona/glac004.
We aimed to evaluate associations of baseline telomere length with overall and annual change in estimated glomerular filtration rate (eGFR) and trajectory of kidney function during an 8-year follow-up. A total of 3 964 participants of the Health and Retirement Study were included. We identified 3 trajectory groups of kidney function: consistently normal (n = 1 163 or 29.3%), normal to impaired (n = 2 306 or 58.2%), and consistently impaired groups (n = 495 or 12.5%). After controlling for age, sex, race, education, smoking, drinking, diabetes, heart disease, blood pressure, body mass index, total cholesterol, and hemoglobin A1c, participants with longer telomere length were 20% less likely (odds ratio = 0.80, 95% confidence interval: 0.69-0.93, p = .003) to have a normal to impaired kidney function trajectory than a consistently normal function trajectory. Telomere length was not associated with changing rate of eGFR over 8 years (p = .45). Participants with longer telomere length were more likely to have consistently normal kidney function.
我们旨在评估基线端粒长度与估计肾小球滤过率（eGFR）的整体和年度变化以及 8 年随访期间肾功能轨迹之间的关联。共有 3964 名健康与退休研究参与者被纳入研究。我们确定了肾功能的 3 个轨迹组：持续正常（n = 1163 或 29.3%）、正常到受损（n = 2306 或 58.2%）和持续受损组（n = 495 或 12.5%）。在控制年龄、性别、种族、教育程度、吸烟、饮酒、糖尿病、心脏病、血压、体重指数、总胆固醇和血红蛋白 A1c 后，端粒长度较长的参与者发生正常到受损肾功能轨迹的可能性降低 20%（比值比 = 0.80，95%置信区间：0.69-0.93，p =.003），而不是持续正常功能轨迹。端粒长度与 8 年内 eGFR 的变化率无关（p =.45）。端粒长度较长的参与者更有可能具有持续正常的肾功能。
