Mazidi Moshen, Rezaie Peyman, Covic Adriac, Malyszko Jolanta, Rysz Jacek, Kengne Andre Pascal, Banach Maciej
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing, China.
Oncotarget. 2017 Sep 8;8(46):80175-80181. doi: 10.18632/oncotarget.20706. eCollection 2017 Oct 6.
Telomere length is an emerging novel biomarker of biologic age, cardiovascular risk and chronic medical conditions. Few studies have focused on the association between telomere length (TL) and kidney function.
We investigated the association between TL and kidney function/prevalent chronic kidney disease (CKD) in US adults.
The National Health and Nutrition Examination Survey (NHANES) participants with measured data on kidney function and TL from 1999 to 2002 were included. Estimated glomerular filtration rate (eGFR) was based on CKD Epidemiology Collaboration (CKD-EPI) equation. Urinary albumin excretion was assessed using urinary albumin-creatinine ratio (ACR). We used multivariable adjusted linear and logistic regression models, accounting for the survey design and sample weights.
Of the 10568 eligible participants, 48.0% (=5020) were men. Their mean age was 44.1 years. eGFR significantly decreased and ACR significantly increased across increasing quarters of TL (all <0.001). The association between TL and kidney function remained robust even after adjusting for potential confounding factors, but the association between TL and ACR was only borderline significant (β-coefficient= -0.012, =0.056).
The association of kidney function with a marker of cellular senescence suggests an underlying mechanism influencing the progression of nephropathy.
端粒长度是一种新兴的生物年龄、心血管风险和慢性疾病的新型生物标志物。很少有研究关注端粒长度（TL）与肾功能之间的关联。
我们调查了美国成年人中端粒长度与肾功能/慢性肾脏病（CKD）患病率之间的关联。
纳入1999年至2002年有肾功能和端粒长度测量数据的美国国家健康与营养检查调查（NHANES）参与者。估算肾小球滤过率（eGFR）基于慢性肾脏病流行病学协作组（CKD-EPI）方程。使用尿白蛋白肌酐比值（ACR）评估尿白蛋白排泄。我们使用多变量调整线性和逻辑回归模型，并考虑了调查设计和样本权重。
在10568名符合条件的参与者中，48.0%（=5020）为男性。他们的平均年龄为44.1岁。随着端粒长度四分位数的增加，eGFR显著降低，ACR显著升高（均<0.001）。即使在调整潜在混杂因素后，端粒长度与肾功能之间的关联仍然很强，但端粒长度与ACR之间的关联仅为临界显著（β系数=-0.012，P=0.056）。
肾功能与细胞衰老标志物之间的关联提示了影响肾病进展的潜在机制。
