Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyüan, Taiwan.
Division of Pediatric Infectious Diseases, Ministry of Health, Putrajaya, Malaysia.
Infection. 2022 Apr;50(2):475-482. doi: 10.1007/s15010-021-01736-0. Epub 2022 Jan 11.
Antimicrobial resistance of nontyphoidal Salmonella (NTS) is a threat to public health worldwide.
A study on longitudinally collected NTS isolates from a medical center in Taiwan from 2011 to 2019 was undertaken. The multidrug resistance (MDR) and extensively drug resistance (XDR) phenotypes were determined according to internationally used definitions. Molecular serotyping was performed on the resistant NTS.
Notably 16.1% (870/5412) of the isolates were MDR, while XDR accounted for 2.1% (111/5412). Both MDR and XDR NTS have increased significantly from 2011 to 2019, especially from 2015 to 2017 (MDR from 9.6% in 2015 to 23.1% 2017; XDR from 1.4% in 2016 to 4.7% in 2017). S. Anatum was the commonest NTS serotype expressing MDR and XDR, in 256/559 (45.8%) and 81/111 (73.0%) of the isolates, respectively, followed by S. Typhimurium and S. Goldcoast. Children < 18 years old contributed to 69.0% of all MDR cases and 64.0% of all XDR cases; majority of them aged less than 5 years.
Increasing MDR and XDR NTS is a threat to public health. MDR and XDR NTS usually caused gastroenteritis in children < 5 years old. Multiple NTS serotypes expressing MDR and XDR indicate multiple food vehicles involved in the transmission. Proper food hygiene practice should never be over-reinforced.
非伤寒沙门氏菌（NTS）的耐药性对全球公共卫生构成威胁。
对 2011 年至 2019 年台湾一家医疗中心纵向收集的 NTS 分离株进行了研究。根据国际上使用的定义，确定了多药耐药（MDR）和广泛耐药（XDR）表型。对耐药性 NTS 进行了分子血清分型。
值得注意的是，16.1%（870/5412）的分离株为 MDR，而 XDR 占 2.1%（111/5412）。2011 年至 2019 年，MDR 和 XDR NTS 的数量均显著增加，尤其是 2015 年至 2017 年（MDR 从 2015 年的 9.6%增加到 2017 年的 23.1%；XDR 从 2016 年的 1.4%增加到 2017 年的 4.7%）。血清型为 S. Anatum 的 NTS 是最常见的表达 MDR 和 XDR 的血清型，分别在 559 株（45.8%）和 111 株（73.0%）分离株中表达，其次是 S. Typhimurium 和 S. Goldcoast。18 岁以下儿童占所有 MDR 病例的 69.0%和所有 XDR 病例的 64.0%；他们中的大多数年龄小于 5 岁。
MDR 和 XDR NTS 的增加对公共卫生构成威胁。MDR 和 XDR NTS 通常引起 5 岁以下儿童的肠胃炎。多种表达 MDR 和 XDR 的 NTS 血清型表明涉及多种食物载体的传播。应始终加强对食品卫生的适当重视。
