Saint James School of Medicine, Arnos Vale, Saint Vincent and the Grenadines.
J Clin Psychol. 2022 Jul;78(7):1331-1340. doi: 10.1002/jclp.23312. Epub 2022 Jan 11.
The study aimed to review recent literature not included in previous reviews and ascertain the correlation between early marijuana use among adolescents, between 12 and 18 years of age, and the development of schizophrenia in early adulthood. A further aim was to determine if the frequency of use of marijuana demonstrated any significant effect on the risk of developing schizophrenia in early adulthood.
Five hundred and ninety-one studies were examined; six longitudinal cohort studies were analyzed using a series of nonparametric tests and meta-analysis.
Nonparametric tests, Friedman tests, and Wilcoxon signed tests showed a highly statistically significant difference in odds ratios for schizophrenia between both high- and low-cannabis users and no-cannabis users.
Both high- and low-frequency marijuana usage were associated with a significantly increased risk of schizophrenia. The frequency of use among high- and low-frequency users is similar in both, demonstrating statistically significant increased risk in developing schizophrenia.
本研究旨在回顾以往综述中未包含的最新文献，并确定青少年（12 至 18 岁）早期吸食大麻与成年早期精神分裂症发展之间的相关性。另一个目的是确定大麻使用的频率是否对成年早期发展为精神分裂症的风险有任何显著影响。
共检查了 591 项研究；使用一系列非参数检验和荟萃分析对 6 项纵向队列研究进行了分析。
非参数检验、Friedman 检验和 Wilcoxon 符号检验显示，高大麻使用者和低大麻使用者与非大麻使用者相比，精神分裂症的优势比存在高度统计学差异。
高频率和低频率使用大麻均与精神分裂症的发病风险显著增加相关。高频率和低频率使用者的使用频率相似，均表明精神分裂症发病风险显著增加。
