National Research Center for Endocrinology of the Ministry of Health of the Russian Federation; A. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation.
National Research Center for Endocrinology of the Ministry of Health of the Russian Federatio.
Probl Endokrinol (Mosk). 2021 Oct 22;67(6):98-112. doi: 10.14341/probl12827.
Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called 'adiponectin paradox'. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states.
脂肪组织主要由不同类型的脂肪组成，是人体最大的内分泌器官之一，具有多种复杂的功能，包括但不限于能量储存、代谢稳态、产热、参与免疫功能以及分泌多种被称为脂联素的生物活性因子。其中含量最丰富的是脂联素。这种脂肪细胞来源的激素具有多种作用，并表现出胰岛素增敏、抗糖尿病、抗肥胖、抗炎、抗动脉粥样硬化、心脏和神经保护作用。与它在不同细胞类型的各种病理事件中的保护作用相反，脂联素可能与几种全身性疾病和恶性肿瘤有关。脂联素水平的降低与 COVID-19 相关的呼吸衰竭有关，这主要归因于一种称为“脂联素悖论”的现象。大量关于脂联素在体内的多种功能的证据来自于动物，主要是啮齿类动物的研究。我们的简明综述完全是关于脂联素的多方面作用及其在不同生理和病理状态下的作用机制。
