银屑病及其合并症中的脂联素：综述。
Adiponectin in psoriasis and its comorbidities: a review.
机构信息
Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St., Boston, MA, 02115, USA.
出版信息
Lipids Health Dis. 2021 Aug 9;20(1):87. doi: 10.1186/s12944-021-01510-z.
Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by abnormal T cell activation and excessive proliferation of keratinocytes. In addition to skin manifestations, psoriasis has been associated with multiple metabolic comorbidities, such as obesity, insulin resistance, and diabetes. An increasing amount of evidence has highlighted the core role of adipokines in adipose tissue and the immune system. This review focus on the role of adiponectin in the pathophysiology of psoriasis and its comorbidities, highlighting the future research avenues.
银屑病是一种慢性、免疫介导的炎症性皮肤病，其特征是 T 细胞异常激活和角质形成细胞过度增殖。除了皮肤表现外，银屑病还与多种代谢合并症相关，如肥胖、胰岛素抵抗和糖尿病。越来越多的证据强调了脂肪因子在脂肪组织和免疫系统中的核心作用。本综述重点讨论了脂联素在银屑病及其合并症的病理生理学中的作用，强调了未来的研究方向。
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