Adana City Training and Research Hospital, Adana, Turkey.
Hacettepe University, Ankara, Turkey.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296211073767. doi: 10.1177/10760296211073767.
to investigate whether the MAPH score, which is a new score that combines blood viscosity biomarkers such as mean platelet volume (MPV), total protein and hematocrit, can be used to predict thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients.
A total of 473 consecutive patients with STEMI were included in the study. Intracoronary tirofiban/abciximab infusion was applied to patients with thrombus load ≥3 and these patients (n = 71) were defined as the patient group with high thrombus load. MPV, age, hematocrit and total protein values of the patients were recorded. High shear rate (HSR) and low shear rate (LSR) were calculated from total protein and hematocrit values. Cut-off values were determined for high thrombus load by using Youden index, and score was determined as 0 or 1 according to cut-offs. The sum of the scores was calculated as the MAPH score.
The mean age of the patients included in the study was 59.6 ± 12.6 (n = 354 male, 74.8%). There was no difference between the groups in terms of gender, HT and DM ( = .127, = .402 and = .576, respectively). In the group with high thrombus load; total protein, MPV and hematocrit values were higher ( < .001, = .001 and = .03, respectively). Comparison of receiver operating characteristic (ROC) curve analysis revealed that the MAPH score had better performance in predicting higher thrombus load than both other self-containing parameters and HSR and LSR.
The MAPH score may be a new score that can be used to determine thrombus burden in STEMI patients.
探讨 MAPH 评分（一种新的评分系统，结合了血小板平均体积（MPV）、总蛋白和血细胞比容等血液粘度生物标志物）是否可用于预测 ST 段抬高型心肌梗死（STEMI）患者的血栓负荷。
共纳入 473 例连续 STEMI 患者。对血栓负荷≥3 的患者行冠状动脉内替罗非班/阿昔单抗输注，将这些患者（n=71）定义为血栓负荷高的患者组。记录患者的血小板平均体积、年龄、血细胞比容和总蛋白值。根据总蛋白和血细胞比容值计算高剪切率（HSR）和低剪切率（LSR）。使用约登指数确定高血栓负荷的截断值，并根据截断值确定 0 分或 1 分的评分。将评分相加得到 MAPH 评分。
本研究共纳入 354 例男性（74.8%）和 74 例女性患者，平均年龄为 59.6±12.6 岁。两组在性别、高血压和糖尿病方面无差异（ = .127、 = .402 和 = .576）。在血栓负荷高的组中，总蛋白、MPV 和血细胞比容值较高（ < .001、 = .001 和 = .03）。受试者工作特征（ROC）曲线分析比较显示，MAPH 评分预测高血栓负荷的性能优于其他自身包含参数、HSR 和 LSR。
MAPH 评分可能是一种新的评分系统，可用于确定 STEMI 患者的血栓负荷。
