挽救性鼓室内类固醇治疗突发性聋：32 例患者的真实临床经验。
Salvage intratympanic steroid therapy for sudden sensorineural hearing loss: our real-life experience in 32 patients.
机构信息
Department of Otolaryngology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Department of Otolaryngology, University Hospital Southampton NHS Foundation Trust, UK.
出版信息
J Laryngol Otol. 2022 Sep;136(9):827-830. doi: 10.1017/S0022215121004254. Epub 2022 Jan 12.
OBJECTIVE
To examine the role of salvage intratympanic steroid injections in patients presenting with idiopathic sudden sensorineural hearing loss following a poor response to initial oral steroid treatment.
METHODS
A retrospective analysis of patient records over the course of four years was conducted, and pure tone thresholds were reviewed before treatment, after oral steroid therapy and six weeks after intratympanic steroid injection therapy.
RESULTS
After oral steroid therapy alone, there was a mean average threshold change of 6.2 dB HL (range, -13.8-33.8 dB). This change was statistically significant for severely affected patients (those with an average presenting threshold of over 71 dB). The mean average threshold improvement following intratympanic steroid injection therapy was 2.9 dB (range, -22.5-61.3 dB); this was not statistically significant.
CONCLUSION
Some patients experienced moderate improvement following intratympanic steroid injection therapy; however, no specific subgroup was identified to benefit more from intratympanic steroid injection therapy.
目的
研究在初始口服类固醇治疗反应不佳的情况下，对特发性突发性聋患者进行挽救性鼓室内类固醇注射的作用。
方法
对四年间的患者记录进行回顾性分析，在治疗前、口服类固醇治疗后和鼓室内类固醇注射治疗后六周评估纯音听阈。
结果
单独使用口服类固醇治疗后，平均平均听阈变化为 6.2 dB HL（范围，-13.8-33.8 dB）。对于重度受影响的患者（平均初始听阈超过 71 dB 的患者），这种变化具有统计学意义。鼓室内类固醇注射治疗后平均平均听阈改善为 2.9 dB（范围，-22.5-61.3 dB）；但无统计学意义。
结论
一些患者在鼓室内类固醇注射治疗后经历了中度改善；然而，没有确定任何特定亚组从鼓室内类固醇注射治疗中获益更多。
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