Noetzlin Sarah, Breville Gautier, Seebach Jörg D, Gastaldi Giacomo
Hôpitaux Universitaires Genève, HUG, Switzerland.
Swiss Med Wkly. 2022 Jan 7;152:w30088. doi: 10.4414/smw.2022.w30088. eCollection 2022 Jan 3.
Glucocorticoids are the mainstay treatment of a variety of inflammatory and autoimmune disorders. Unfortunately, metabolic side effects, drug interactions and adverse reactions commonly lead to glucocorticoid-related side effects, thereby compromising their intended anti-inflammatory and immunosuppressive effects. The goal of this review is to help clinicians to monitor the broad spectrum of side effects of short-term systemic glucocorticoid administration, defined as glucocorticoid treatment shorter than 30 days. We review the various systems affected, with a focus on metabolic conditions and hyperglycaemia management.
糖皮质激素是多种炎症性和自身免疫性疾病的主要治疗药物。不幸的是，代谢副作用、药物相互作用和不良反应通常会导致糖皮质激素相关的副作用，从而损害其预期的抗炎和免疫抑制作用。本综述的目的是帮助临床医生监测短期全身性糖皮质激素给药（定义为糖皮质激素治疗时间短于30天）所产生的广泛副作用。我们回顾了受影响的各个系统，重点关注代谢状况和高血糖管理。
