给予阿莫西林-克拉维酸的患者脑脊液对流感嗜血杆菌的杀菌活性。
Bactericidal activity against Haemophilus influenzae of cerebrospinal fluid of patients given amoxicillin-clavulanic acid.
作者信息
Decazes J M, Bure A, Wolff M, Kitzis M D, Pangon B, Modai J
机构信息
Department of Infectious Diseases, Saint-Louis Hospital, Paris, France.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):2018-9. doi: 10.1128/AAC.31.12.2018.
Abstract
Patients with purulent meningitis received amoxicillin-clavulanic acid (200/20 mg/kg [body weight] per day). Clavulanic acid levels in cerebrospinal fluid were less than or equal to 0.05 micrograms/ml in 5 of 18 samples and ranged from 0.1 to 0.8 micrograms/ml in the others. Of 12 cerebrospinal fluid samples tested, 10 lacked bactericidal activity in vitro against a beta-lactamase-producing strain of Haemophilus influenzae.
摘要
患有化脓性脑膜炎的患者接受了阿莫西林-克拉维酸（每天200/20毫克/千克[体重]）治疗。18份样本中有5份脑脊液中的克拉维酸水平小于或等于0.05微克/毫升，其他样本的水平在0.1至0.8微克/毫升之间。在检测的12份脑脊液样本中，有10份在体外对产β-内酰胺酶的流感嗜血杆菌菌株缺乏杀菌活性。
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