阿莫西林和克拉维酸钾在脑膜炎患者脑脊液中的渗透情况。
Penetration of amoxicillin and potassium clavulanate into the cerebrospinal fluid of patients with inflamed meninges.
作者信息
Bakken J S, Bruun J N, Gaustad P, Tasker T C
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):481-4. doi: 10.1128/AAC.30.3.481.
Abstract
A single intravenous dose of 2.0 g of amoxicillin and 0.2 g of potassium clavulanate was given to patients with bacterial meningitis, and the pharmacokinetics of both drugs in the cerebrospinal fluid (CSF) and plasma were evaluated. Twenty-one patients aged 14 to 76 years were studied. Both amoxicillin and potassium clavulanate were detectable in the CSF as early as 1 h and reached peak concentrations by approximately 2 h. The highest mean CSF concentrations were 2.25 micrograms/ml for amoxicillin and 0.25 micrograms/ml for potassium clavulanate and were found in patients with moderately or severely inflamed meninges. The CSF penetration relative to plasma for amoxicillin and potassium clavulanate was 5.8 and 8.4%, respectively. These levels suggest that the amoxicillin-potassium clavulanate combination may be effective for the treatment of bacterial meningitis caused by beta-lactamase-producing pathogens.
摘要
对患有细菌性脑膜炎的患者静脉注射单次剂量2.0克阿莫西林和0.2克克拉维酸钾，并评估两种药物在脑脊液（CSF）和血浆中的药代动力学。研究了21名年龄在14至76岁之间的患者。阿莫西林和克拉维酸钾在脑脊液中最早在1小时即可检测到，约2小时达到峰值浓度。阿莫西林的最高平均脑脊液浓度为2.25微克/毫升，克拉维酸钾为0.25微克/毫升，在中度或重度炎症性脑膜炎患者中发现。阿莫西林和克拉维酸钾相对于血浆的脑脊液渗透率分别为5.8%和8.4%。这些水平表明阿莫西林-克拉维酸钾组合可能对治疗由产β-内酰胺酶病原体引起的细菌性脑膜炎有效。
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