Lee Bor-Shiunn, Lin Yi-Chen, Hsu Wei-Chieh, Hou Cheng-Hung, Shyue Jing-Jong, Hsiao Shu-Yun, Wu Pei-Ju, Lee Ying-Te, Luo Shyh-Chyang
Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, Taipei 10048, Taiwan.
Department of Materials Science and Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
ACS Appl Bio Mater. 2020 Jan 21;3(1):486-494. doi: 10.1021/acsabm.9b00939. Epub 2019 Dec 24.
In this study, a nanocomposite coating composed of polydopamine, functionalized poly(3,4-ethylenedioxythiophene) (PEDOT), and silver nanoparticles (AgNPs) was synthesized through layer-by-layer deposition. Biomimitic polydopamine and hydroxyl-functionalized PEDOT were used to enhance the adhesion strength. The deposition of PEDOT functionalized with zwitterionic phosphorylcholine can contribute to the antifouling property. After immersion in the AgNO solution, Ag ions were adsorbed on PEDOT films and further reduced to form AgNPs spontaneously, which conferred antibacterial properties on these nanocomposite films. and were chosen to represent two common Gram-negative and Gram-positive oral pathogens. We further conducted inductively coupled plasma mass spectrometry to confirm that the Ag ions released from these nanocomposite films did not exert adverse effects on the human body. These results suggested that, when applied to stainless steel orthodontic appliances, these durable antifouling and antibacterial coatings may be useful for avoiding bacterial infection.
在本研究中，通过层层沉积合成了一种由聚多巴胺、功能化聚（3,4-乙撑二氧噻吩）（PEDOT）和银纳米颗粒（AgNPs）组成的纳米复合涂层。仿生聚多巴胺和羟基功能化的PEDOT用于提高粘附强度。用两性离子磷酰胆碱功能化的PEDOT的沉积有助于防污性能。浸入AgNO溶液后，Ag离子吸附在PEDOT薄膜上并进一步自发还原形成AgNPs，这赋予了这些纳米复合薄膜抗菌性能。选择 和 来代表两种常见的革兰氏阴性和革兰氏阳性口腔病原体。我们进一步进行了电感耦合等离子体质谱分析，以确认从这些纳米复合薄膜中释放的Ag离子不会对人体产生不利影响。这些结果表明，当应用于不锈钢正畸矫治器时，这些耐用的防污抗菌涂层可能有助于避免细菌感染。
