Kim Soochan, Cho Misuk, Lee Youngkwan
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
ACS Appl Bio Mater. 2020 Dec 21;3(12):8997-9001. doi: 10.1021/acsabm.0c01242. Epub 2020 Dec 9.
We created a cost-benefit analysis and swift point-of-care (PoC) testing for early stage Parkinson's disease (PD) that delivers the possibility of providing sensitive, rapid, and user-friendly analysis in home diagnostics applications. α-Synuclein (α-Syn) is considered a meaningful biomarker for the diagnosis of early stage PD. The PoC platform for diagnosis of PD is simply constructed with a conductive polymer and an aptamer receptor on a screen-printed electrode and exhibits a remarkable low detection limit of 1 × 10 fM. The developed PoC platform will offer an opportunity for individuals to conveniently and periodically check the progress of the diseases and success through expansion as a checkup platform for other diseases.
我们开展了一项成本效益分析，并针对早期帕金森病（PD）开发了即时护理（PoC）快速检测方法，该方法有望在家庭诊断应用中实现灵敏、快速且用户友好的分析。α-突触核蛋白（α-Syn）被认为是早期PD诊断的重要生物标志物。用于PD诊断的PoC平台由导电聚合物和丝网印刷电极上的适配体受体简单构建而成，检测限低至1×10 fM，表现出色。所开发的PoC平台将为个人提供机会，方便且定期地检查疾病进展情况，并有望通过扩展成为其他疾病的检查平台而取得成功。
