Li F P, Gimbrere K, Ritz J, Saito H, Longtine J A
Clinical Studies Section, Dana-Farber Cancer Institute, Boston, MA 02115.
Cancer. 1987 Nov 1;60(9):2213-8. doi: 10.1002/1097-0142(19871101)60:9<2213::aid-cncr2820600918>3.0.co;2-j.
A woman was treated for Hodgkin's disease, remained disease-free for 25 years, and then developed waxing and waning adenopathy during the next 2 years. The histologic examination of a lymph node biopsy specimen showed a T-cell non-Hodgkin's lymphoma. The patient's indolent clinical course prompted a second biopsy to obtain tissue for T-cell receptor gene rearrangement studies. A southern blot analysis using a human T-cell receptor beta chain probe showed a new band of rearranged DNA, which confirmed the diagnosis of T-cell lymphoma.
一名女性曾接受霍奇金病治疗，25年来病情一直未复发，但在接下来的2年中出现了时轻时重的淋巴结病。淋巴结活检标本的组织学检查显示为T细胞非霍奇金淋巴瘤。患者病情进展缓慢，促使进行第二次活检以获取组织用于T细胞受体基因重排研究。使用人T细胞受体β链探针进行的Southern印迹分析显示出一条新的重排DNA条带，这证实了T细胞淋巴瘤的诊断。
