职业暴露与肺癌风险——CARTaGENE研究分析
Occupational Exposures and Lung Cancer Risk-An Analysis of the CARTaGENE Study.
作者信息
Moayedi-Nia Saeedeh, Pasquet Romain, Siemiatycki Jack, Koushik Anita, Ho Vikki
机构信息
Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada (Ms Moayedi-Nia, Dr Siemiatycki, Dr Koushik, Dr Ho); and Health Innovation and Evaluation Hub, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada (Dr Pasquet, Dr Siemiatycki, Dr Koushik, Dr Ho).
出版信息
J Occup Environ Med. 2022 Apr 1;64(4):295-304. doi: 10.1097/JOM.0000000000002481. Epub 2022 Jan 11.
OBJECTIVE
To determine the associations between prevalent occupational agents and lung cancer risk.
METHODS
A case-cohort design (ncases= 147; nsub-cohort= 1,032) was nested within the CARTaGENE prospective cohort study. The Canadian Job Exposure Matrix was used to determine the probability of exposure to 27 agents in participants' longest-held jobs. Multivariable logistic regression with robust variance estimators was used to determine the associations between each agent and lung cancer risk while adjusting for established lung cancer risk factors.
RESULTS
Increased lung cancer risk was observed among those exposed to ashes, calcium sulfate, formaldehyde, cooking fumes, alkanes, aliphatic aldehydes, and cleaning agents. Lower lung cancer risk was found among participants exposed to carbon monoxide and polycyclic aromatic hydrocarbons from petroleum.
CONCLUSION
Our findings support the role of several occupational agents, for which we have limited knowledge, in contributing to lung cancer risk.
目的
确定常见职业接触物与肺癌风险之间的关联。
方法
一项病例队列设计（病例数 = 147；亚队列数 = 1032）嵌套于CARTaGENE前瞻性队列研究中。使用加拿大工作接触矩阵来确定参与者最长从事工作中接触27种物质的概率。采用具有稳健方差估计量的多变量逻辑回归来确定每种接触物与肺癌风险之间的关联，同时对已确定的肺癌风险因素进行校正。
结果
在接触灰烬、硫酸钙、甲醛、烹饪油烟、烷烃、脂肪醛和清洁剂的人群中观察到肺癌风险增加。在接触一氧化碳和石油来源的多环芳烃的参与者中发现肺癌风险较低。
结论
我们的研究结果支持了几种我们了解有限的职业接触物在导致肺癌风险方面的作用。
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