钙调素二核苷酸依赖的钙内流介导紫杉醇诱导的轴突变性。
cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel.
机构信息
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
出版信息
J Cell Biol. 2022 Feb 7;221(2). doi: 10.1083/jcb.202112021. Epub 2022 Jan 12.
Abstract
Activation of the NAD hydrolase domain of Sarm1 mediates axonal degeneration caused by chemotherapy drugs, but the downstream events are unknown. In this issue, Li and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106080) demonstrate that cADPR, a breakdown product of NAD, mediates paclitaxel-induced axonal degeneration by promoting influx of calcium into the axons.
摘要
Sarm1 的 NAD 水解酶结构域的激活介导了化疗药物引起的轴突变性，但下游事件尚不清楚。在本期杂志中，Li 及其同事（2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106080）表明，NAD 的分解产物 cADPR 通过促进钙离子流入轴突介导了紫杉醇诱导的轴突变性。
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