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氨苄西林、氯霉素与甲氧苄啶-磺胺甲恶唑(TMP-SMZ)治疗临床实践中伤寒沙门菌感染的比较

[Comparison of ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole (TMP-SMZ) for the treatment of Salmonella typhi infections in clinical practice].

作者信息

Colak H, Usluer G

机构信息

Anadolu U. Tip Fak. Infeksiyon Hastaliklari Anabilim Dali.

出版信息

Mikrobiyol Bul. 1987 Jan;21(1):20-6.

PMID:3502016
Abstract

Ninety-four patients with Salmonella typhi infection hospitalized and treatment. Widal test results, blood cultures, stool cultures and physical examination findings were admitted infection criteria. Ampicillin used 100 mg/kg/day four divided dose in 52 patients, chloramphenicol used 2g/day four divided dose in 28 patients and TMP-SMZ 160-800 mg used bid in 14 patients. All of the treatments applied for 2 weeks. Ampicillin 92.30%, chloramphenicol 82.15% and TMP-SMZ 85.71% were found success. Fever dropped in normal degrees 3.43 +/- 1.71 days in ampicillin group, 3.47 +/- 1.13 days in chloramphenicol group and 3 +/- 1.41 days in TMP-SMZ group.

摘要

94例伤寒沙门菌感染患者住院并接受治疗。维达试验结果、血培养、粪便培养及体格检查结果为确诊感染标准。52例患者使用氨苄西林,剂量为100mg/kg/天,分4次给药;28例患者使用氯霉素,剂量为2g/天,分4次给药;14例患者使用复方磺胺甲恶唑,剂量为160 - 800mg,每日2次。所有治疗均持续2周。发现氨苄西林治疗成功率为92.30%,氯霉素为82.15%,复方磺胺甲恶唑为85.71%。氨苄西林组发热在3.43±1.71天降至正常水平,氯霉素组为3.47±1.13天,复方磺胺甲恶唑组为3±1.41天。

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