Gilman R H, Terminel M, Levine M M, Hernandez-Mendosa P, Calderone E, Vasquez V, Martinez E, Snyder M J, Hornick R B
J Infect Dis. 1975 Dec;132(6):630-6. doi: 10.1093/infdis/132.6.630.
The efficacy of orally administered trimethoprim-sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol-resistant and endemic chloramphenicol-sensitive Salmonella typhi. Both drug regimens were effective and of comparable value in treatment of chloramphenicol-resistant infections, as measured by duration of fever (124 hr and 115 hr, respectively) and duration of bacteremia (1.0 and 0.4 days, respectively). Trimethoprim-sulfamethoxazole therapy of infections due to chloramphenicol-sensitive S. typhi resulted in more rapid lysis of fever than did amoxicillin therapy. Trimethoprim and sulfamethoxazole were not synergistic in vitro against the chloramphenicol-resistant strain of S. typhi, and the role of sulfamethoxazole in treatment of such infections appears to be minimal. Oral administration of trimethoprim-sulfamethoxazole is effective therapy of chloramphenicol-resistant, and probably of ampicillin-amoxicillin-resistant, typhoid fever.
在治疗由耐氯霉素的流行株和对氯霉素敏感的地方性伤寒杆菌引起的伤寒热时，对口服甲氧苄啶-磺胺甲恶唑与口服阿莫西林的疗效进行了比较。两种药物治疗方案均有效，在耐氯霉素感染的治疗中价值相当，以发热持续时间（分别为124小时和115小时）和菌血症持续时间（分别为1.0天和0.4天）衡量。对于对氯霉素敏感的伤寒杆菌引起的感染，甲氧苄啶-磺胺甲恶唑治疗比阿莫西林治疗能使发热更快消退。甲氧苄啶和磺胺甲恶唑在体外对耐氯霉素的伤寒杆菌菌株没有协同作用，磺胺甲恶唑在治疗此类感染中的作用似乎很小。口服甲氧苄啶-磺胺甲恶唑是治疗耐氯霉素以及可能耐氨苄西林-阿莫西林的伤寒热的有效疗法。
