中心血管代谢指数与非酒精性脂肪肝的相关性：来自一般人群的研究结果。
Association between the cardiometabolic index and non-alcoholic fatty liver disease: insights from a general population.
机构信息
Department of Cardiology, Jiujiang First People's Hospital, Jiujiang, 332000, China.
Department of Cardiology, Jiangxi Provincial People's Hospital, Nanchang, 330006, China.
出版信息
BMC Gastroenterol. 2022 Jan 12;22(1):20. doi: 10.1186/s12876-022-02099-y.
BACKGROUND
Emerging evidence suggests that cardiometabolic index (CMI) is closely related to diabetes, hypertension, stroke, cardiovascular disease, and kidney disease, which implies that CMI has the value as an indicator of metabolic diseases. However, data on the relationships between CMI and non-alcoholic fatty liver disease (NAFLD) risks have not been reported. This study is designed to examine the association between CMI and NAFLD in the general population.
METHODS
The current study included 14,251 subjects whose CMI was the product of triglyceride/high-density lipoprotein cholesterol ratio and waist-to-height ratio. Linear regression was used to analyze the correlation between baseline information and CMI, logistic regression was used to study the relationship between CMI and NAFLD, and subgroup analysis was used to explore potential high-risk groups.
RESULTS
After adjusted for potential confounding factors, higher CMI was independently associated with NAFLD, in which every additional standard deviation (SD) of CMI increased the risk of NAFLD by 28% (OR 1.28 per SD increase, 95% CI 1.19-1.37, P for trend < 0.0001). There were also significant differences in CMI-related NAFLD risk among different ages and genders, in which the CMI-related NAFLD risk in young people was significantly higher than that in other age groups (OR = 2.63 per SD increase for young people, OR = 1.38 per SD increase for young and middle-aged people, OR = 1.18 per SD increase for middle-aged and elderly people; OR = 1.14 per SD increase for elderly people, P for interaction = 0.0010), and the CMI-related NAFLD risk in women was significantly higher than that in men (OR = 1.58 per SD increase for women, OR = 1.26 per SD increase for men, P for interaction = 0.0045).
CONCLUSIONS
Current studies have found that after excluding potential confounding factors, higher CMI in the general population is independently associated with NAFLD risk.
背景
新出现的证据表明，心脏代谢指数（CMI）与糖尿病、高血压、中风、心血管疾病和肾脏疾病密切相关，这意味着 CMI 具有作为代谢疾病指标的价值。然而，关于 CMI 与非酒精性脂肪肝（NAFLD）风险之间关系的数据尚未报道。本研究旨在检验一般人群中 CMI 与 NAFLD 之间的相关性。
方法
本研究纳入了 14251 名受试者，他们的 CMI 是甘油三酯/高密度脂蛋白胆固醇比值和腰高比的乘积。线性回归用于分析基线信息与 CMI 之间的相关性，逻辑回归用于研究 CMI 与 NAFLD 的关系，亚组分析用于探索潜在的高危人群。
结果
在调整了潜在混杂因素后，较高的 CMI 与 NAFLD 独立相关，其中 CMI 每增加一个标准差（SD），NAFLD 的风险增加 28%（OR 每 SD 增加 1.28，95%CI 1.19-1.37，P 趋势<0.0001）。在不同年龄和性别中，CMI 与 NAFLD 风险的相关性也存在显著差异，其中年轻人的 CMI 与 NAFLD 风险明显高于其他年龄组（OR 每 SD 增加年轻人为 2.63，OR 每 SD 增加年轻人和中年人为 1.38，OR 每 SD 增加中年人和老年人为 1.18；OR 每 SD 增加老年人为 1.14，P 交互=0.0010），女性的 CMI 与 NAFLD 风险明显高于男性（OR 每 SD 增加女性为 1.58，OR 每 SD 增加男性为 1.26，P 交互=0.0045）。
结论
目前的研究发现，在排除潜在混杂因素后，一般人群中较高的 CMI 与 NAFLD 风险独立相关。
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