Yang Yang, Zeng Cheng, Jin Zhiqiang, Huang Yi, Liu Huabao
Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China.
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, 401336, Chongqing, China.
BMC Gastroenterol. 2025 Jul 29;25(1):537. doi: 10.1186/s12876-025-04127-z.
Cardiometabolic Index (CMI) is positively correlated with liver fibrosis in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but its association with mortality risk in MASLD patients remains unclear.
This study utilized data from NHANES III and linked it with the mortality database up to December 31, 2019. Cox regression analysis was used to examine the relationship between CMI and mortality rates. Linear regression analysis was conducted to explore the correlation between CMI and the TyG index, and mediation analysis was performed to investigate the potential mechanisms underlying the association between CMI and mortality.
The study included 2,260 MASLD patients with a median age of 51 years and a median CMI of 2.5. In the fully adjusted Cox regression model, CMI was positively associated with all-cause mortality (per 1-SD increase, HR = 1.04, 95% CI = 1.00-1.08) and other-cause mortality rates (per 1-SD increase, HR = 1.25, 95% CI = 1.12–1.40), but not with cardiovascular or cancer-related mortality. Mediation analysis indicated that the TyG index mediated 16.6% of the association between CMI and all-cause mortality.
CMI in MASLD patients is associated with an increased risk of all-cause and other-cause mortality.
The online version contains supplementary material available at 10.1186/s12876-025-04127-z.
在代谢功能障碍相关脂肪性肝病（MASLD）患者中，心脏代谢指数（CMI）与肝纤维化呈正相关，但其与MASLD患者死亡风险的关联尚不清楚。
本研究利用了美国国家健康与营养检查调查（NHANES）III的数据，并将其与截至2019年12月31日的死亡率数据库相链接。采用Cox回归分析来检验CMI与死亡率之间的关系。进行线性回归分析以探索CMI与TyG指数之间的相关性，并进行中介分析以研究CMI与死亡率之间关联的潜在机制。
该研究纳入了2260例MASLD患者，中位年龄为51岁，中位CMI为2.5。在完全调整的Cox回归模型中，CMI与全因死亡率（每增加1个标准差，HR = 1.04，95%CI = 1.00 - 1.08）和其他原因死亡率（每增加1个标准差，HR = 1.25，95%CI = 1.12 - 1.40）呈正相关，但与心血管或癌症相关死亡率无关。中介分析表明，TyG指数介导了CMI与全因死亡率之间16.6%的关联。
MASLD患者的CMI与全因和其他原因死亡风险增加相关。
在线版本包含可在10.1186/s12876 - 025 - 04127 - z获取的补充材料。
