Center for Advanced Materials Research, Science and Technology Experimental Platform, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai, 519085, China.
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Angew Chem Int Ed Engl. 2022 Mar 7;61(11):e202117709. doi: 10.1002/anie.202117709. Epub 2022 Jan 25.
Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation-induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as models to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration (RIV) mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single-molecule motion and macroscopic molecular motion via fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging-guided photodynamic therapy applications, which confirms the great application potential of this new AIE-active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.
分子运动在自然界中无处不在，它们在所有的活动中都起着不可改变的内在作用。然而，探索合适的模型来破译分子运动是研究人员极其重要但极具挑战性的任务。考虑到聚集诱导发光（AIE）发光体具有独特的优点，可以可视化分子运动，因此构建新的 AIE 体系作为研究分子运动的模型特别吸引人。在这里，基于限制分子内振动（RIV）机制构建了一种新型喹喔啉（QLZ）AIE 体系。结果表明，QLZ 可以通过荧光变化作为可视化单分子运动和宏观分子运动的理想模型。此外，通过进一步精细设计这个令人印象深刻的核心，实现了高效的活性氧物种生成，并实现了荧光成像引导的光动力治疗应用，这证实了这个新的 AIE 活性 QLZ 核心具有巨大的应用潜力。因此，这项工作不仅提供了一个可视化分子运动的理想模型，也为 AIEgens 的应用开辟了新的途径。
