Bethegnies G, Dupuis M H, Marcincal-Lefebvre A, Trupin N, Brunet C
Farmaco Sci. 1986 Jun;41(6):471-7.
Some 7-chloro(phenylthio)-4-phenylaminoquinolines substituted in the benzene rings were prepared and subject to the Winter test for potential antiinflammatory activity and the acetic acid test for analgesic activity. Derivative (I) was devoid of antiinflammatory properties but showed interesting analgesic activity although this was 30 times weaker than that of indomethacin used as reference substance. The DL50/DE50 ratio is greater than 16 for derivative (I) and 3 for indomethacin. The other compounds had no or only slight activity.
制备了一些在苯环上有取代基的7-氯（苯硫基）-4-苯基氨基喹啉，并对其进行了潜在抗炎活性的温特试验和镇痛活性的醋酸试验。衍生物（I）没有抗炎特性，但显示出有趣的镇痛活性，尽管其活性比用作参比物质的吲哚美辛弱30倍。衍生物（I）的LD50/ED50比值大于16，吲哚美辛的该比值为3。其他化合物没有活性或只有轻微活性。
