Del'vig A A
Biokhimiia. 1978;43(4):579-91.
Localization, physico-chemical and catalytic properties and possible biological functions of polynucleotide phosphorylase (PNPase) from animal tissues are discussed. In animal tissue cells PNPase has multiple localization; the major amount of the enzyme is localized in the endoplasmic reticulum ribosomes. In the nuclei PNPase, similar to other endo- and exo-RNAses participates in the processing of precursor molecules of mature forms of RNA, whereas in the cytoplasm it is involved in the destruction of polyribosomes in the polyribosomes of rapidly growing tissues the activity of PNPase is extremely decreased. The mechanisms regulating the PNPase activity in rapidly growing tissues are discussed.
本文讨论了动物组织中多核苷酸磷酸化酶（PNPase）的定位、物理化学和催化特性以及可能的生物学功能。在动物组织细胞中，PNPase具有多种定位；该酶的主要部分定位于内质网核糖体。在细胞核中，PNPase与其他内切和外切核糖核酸酶类似，参与成熟形式RNA前体分子的加工，而在细胞质中，它参与快速生长组织的多核糖体中多核糖体的破坏，在这些组织中PNPase的活性极度降低。本文还讨论了调节快速生长组织中PNPase活性的机制。
