Department of Chemistry, GLA University, Mathura, Uttar Pradesh 281406, India.
Department of Chemistry, GD Goenka University, Gurgaon, Haryana, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Apr 5;270:120819. doi: 10.1016/j.saa.2021.120819. Epub 2022 Jan 6.
Spectrophotometry is a quick and reliable method for determining the composition of a variety of complex drug mixtures. Several mathematical models are available for the resolution of complex multicomponent UV spectra. UV spectrophotometric methods have the inherent capacity to resolve the interlaced spectra of complex mixtures quickly and appropriately, particularly for quantitative determination of components of mixture where several costly tools are not available. These methods also have the benefit of lower operational costs as they are operated using lesser amounts of analytical grade solvents and generate less waste. In this review, we discussed the theoretical background of different UV spectrometric methods for quantitative analysis of drug mixtures. The main focus of this review is to describe and report applications of extended Beer's law-based multicomponent analysis and to highlight the recent developments in the simultaneous determination of drug components from their complex mixtures.
分光光度法是一种快速可靠的方法，可用于确定各种复杂药物混合物的成分。有几种数学模型可用于解析复杂的多组分紫外光谱。紫外分光光度法具有快速、适当地解析复杂混合物交叠光谱的固有能力，特别是对于混合物成分的定量测定，在这种情况下，没有几种昂贵的工具可供使用。这些方法还具有操作成本较低的优点，因为它们使用的分析级溶剂较少，产生的废物也较少。在这篇综述中，我们讨论了用于药物混合物定量分析的不同紫外分光光度法的理论背景。本篇综述的主要重点是描述和报告基于扩展比尔定律的多组分分析的应用，并强调从复杂混合物中同时测定药物成分的最新进展。
