Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University, Ras al Khaimah, UAE.
Pak J Pharm Sci. 2021 Nov;34(6):2109-2119.
Solid lipid nanoparticles (SLNs) have several potential applications in the topical drug delivery. The current project aimed to prepare and characterize SLNs loaded with vitamin E for topical administration and incorporating the prepared SLNs in a cream base. Further, the permeation of prepared SLNs was studied through a synthetic membrane and the release profiles were compared with vitamin E cream. The prepared SLNs were subjected to stability studies at two different temperatures. Hot homogenization followed by dilution technique was used for the preparation of SLNs. In this project, PDMS membrane was used to mimic the skin for permeation studies. From the results of this study, it can be concluded that prepared SLNs had enhanced the permeation of vitamin E as compared to vitamin E cream.
固体脂质纳米粒 (SLNs) 在局部药物递送中有多种潜在应用。本项目旨在制备并表征负载维生素 E 的 SLNs 用于局部给药，并将制备的 SLNs 掺入乳膏基质中。此外，还通过合成膜研究了制备的 SLNs 的渗透情况，并将其释放曲线与维生素 E 乳膏进行了比较。在两种不同温度下对制备的 SLNs 进行了稳定性研究。采用热匀化后稀释技术制备 SLNs。在本项目中，使用 PDMS 膜模拟皮肤进行渗透研究。从这项研究的结果可以得出结论，与维生素 E 乳膏相比，制备的 SLNs 增强了维生素 E 的渗透。
