a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):255-262. doi: 10.1080/21691401.2017.1307207. Epub 2017 Apr 3.
To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.
为避免潜在的系统性毒性，采用热熔匀化法联合超声法制备了固体脂质纳米粒（SLN）作为伊维菌素（IVM）经皮传递的载体。所制备的 SLN 呈近似球形且具有良好的稳定性。IVM 以无定形状态包封于 SLN 中，并由于高包封效率（EE）而显示出从 SLN 中延长的释放而无突释。与伊维菌素混悬剂相比，来自 SLN 的 IVM 的累积透皮渗透明显增加。这些结果表明，所提出的 SLN 可被视为 IVM 的经皮传递的有效载体，以有效治疗疥疮。
