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Metabolic activation of dibenzo(a,h)anthracene and its dihydrodiols to bacterial mutagens.

作者信息

Wood A W, Levin W, Thomas P E, Ryan D, Karle J M, Yagi H, Jerina D M, Conney A H

出版信息

Cancer Res. 1978 Jul;38(7):1967-73.

PMID:350381
Abstract
摘要

相似文献

1
Metabolic activation of dibenzo(a,h)anthracene and its dihydrodiols to bacterial mutagens.
Cancer Res. 1978 Jul;38(7):1967-73.
2
The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes.
Mol Pharmacol. 1979 Sep;16(2):643-55.
3
Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens.二苯并(a,h)蒽向反式二氢二醇的立体选择性代谢及其对细菌诱变剂的激活作用。
Environ Health Perspect. 1990 Aug;88:37-41. doi: 10.1289/ehp.908837.
4
Metabolism of 6-methylbenz[a]anthracene by rat liver microsomes and mutagenicity of metabolites.大鼠肝脏微粒体对6-甲基苯并[a]蒽的代谢及其代谢产物的致突变性
Cancer Res. 1985 Sep;45(9):4006-14.
5
Epoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene.大鼠肝细胞色素P-450和P-448催化的环氧化反应发生在8-甲基苯并[a]蒽的8,9-双键的不同面上。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6802-6. doi: 10.1073/pnas.79.22.6802.
6
Mutagenic effect of 7, 12-dimethylbenz[a]anthracene-epidioxide on Salmonella typhimurium.
Mol Pharmacol. 1979 Jan;15(1):189-91.
7
Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: evidence for bay region activation of carcinogenic polycyclic hydrocarbons.
Biochem Biophys Res Commun. 1976 Sep 20;72(2):680-6. doi: 10.1016/s0006-291x(76)80093-9.
8
Metabolic activation of 3-methylcholanthrene and its metabolites to products mutagenic to bacterial and mammalian cells.
Cancer Res. 1978 Oct;38(10):3398-404.
9
Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.
Jpn J Cancer Res. 1987 Feb;78(2):153-61.
10
The effect of dietary protein deficiency on the ability of isolated hepatic microsomes to alter the mutagenicity of a primary and a secondary carcinogen.
Cancer Res. 1974 Jan;34(1):119-23.

引用本文的文献

1
Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.并苯[a,h]蒽四个对映体 3,4-二羟基-1,2-环氧化物的致突变性和致癌性。
Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.
2
Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.苯并(a)芘代谢物-DNA加合物的形成与持久性。
Environ Health Perspect. 1985 Oct;62:31-9. doi: 10.1289/ehp.856231.
3
Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens.
二苯并(a,h)蒽向反式二氢二醇的立体选择性代谢及其对细菌诱变剂的激活作用。
Environ Health Perspect. 1990 Aug;88:37-41. doi: 10.1289/ehp.908837.
4
Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.鉴定导致哺乳动物细胞发生诱变的7,12-二甲基苯并[a]蒽代谢物。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):862-6. doi: 10.1073/pnas.76.2.862.
5
Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.7,12-二甲基苯并[a]蒽的四种反式-3,4-二氢二醇代谢物的鉴定及其进一步代谢后的体外DNA结合活性。
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5466-70. doi: 10.1073/pnas.75.11.5466.