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The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes.

作者信息

Nordqvist M, Thakker D R, Levin W, Yagi H, Ryan D E, Thomas P E, Conney A H, Jerina D M

出版信息

Mol Pharmacol. 1979 Sep;16(2):643-55.

PMID:514264
Abstract
摘要

相似文献

1
The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes.
Mol Pharmacol. 1979 Sep;16(2):643-55.
2
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Chem Res Toxicol. 2003 Dec;16(12):1581-8. doi: 10.1021/tx0341310.
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Metabolism of 8-hydroxymethylbenz[a]anthracene by rat liver microsomes. Stereochemistry of dihydrodiol metabolites and the effect of enzyme induction.
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Rat hepatic nuclear cytochrome P-450 and epoxide hydrase in membranes prepared by two methods: similarities with the microsomal enzymes.通过两种方法制备的大鼠肝细胞核膜中的细胞色素P-450和环氧化物水解酶：与微粒体酶的相似性
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Epoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene.大鼠肝细胞色素P-450和P-448催化的环氧化反应发生在8-甲基苯并[a]蒽的8,9-双键的不同面上。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6802-6. doi: 10.1073/pnas.79.22.6802.

引用本文的文献

1
Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.并苯[a,h]蒽四个对映体 3,4-二羟基-1,2-环氧化物的致突变性和致癌性。
Carcinogenesis. 2013 Sep;34(9):2184-91. doi: 10.1093/carcin/bgt164. Epub 2013 May 13.
2
Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.二苯并[a,h]蒽（±）反式-1,2-二氢二醇和屈（±）反式-3,4-二氢二醇向邻位二氢二醇环氧化物的代谢转化。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4270-3. doi: 10.1073/pnas.78.7.4270.
3
Activation mechanisms to chemical toxicity.
化学毒性的激活机制。
Arch Toxicol. 1987;60(1-3):5-15. doi: 10.1007/BF00296939.
4
Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens.二苯并(a,h)蒽向反式二氢二醇的立体选择性代谢及其对细菌诱变剂的激活作用。
Environ Health Perspect. 1990 Aug;88:37-41. doi: 10.1289/ehp.908837.