Porflitt-Rodríguez María, Guzmán-Arriagada Valentina, Sandoval-Valderrama Romina, Tam Charmaine S, Pavicic Francisca, Ehrenfeld Pamela, Martínez-Huenchullán Sergio
School of Physical Therapy, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile.
Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Metabolism. 2022 Apr;129:155137. doi: 10.1016/j.metabol.2022.155137. Epub 2022 Jan 14.
Fibroblast growth factor 21 (FGF21) has been suggested to improve metabolism during aerobic exercise in obesity. However, the variability of exercise interventions gives rise to discrepancies in the field. Therefore, we aimed to systematically review the available literature regarding the effects of aerobic exercise on FGF21 in the context of overweight and obesity. Our search included original articles published between 2009 and November 2021 found in PubMed, Science Direct, and Medline. Clinical and preclinical studies were included. Studies, where subjects or animals presented with other conditions (e.g., cancer, stroke), were excluded. From an initial 43 studies, 19 (clinical studies = 9; preclinical studies = 10) were eligible for inclusion in this review. The main findings were that acute exercise tended to increase circulatory levels of FGF21. In contrast, chronic exercise programs (≥4 weeks) had the opposite effect along with inducing mRNA and protein increases of FGF receptors and β-klotho in adipose tissue, liver, and skeletal muscle. In conclusion, both clinical and preclinical studies showed that aerobic exercise exerts changes in circulatory and tissue FGF21, along with its receptors and co-receptor. Future research is needed to elucidate the mechanisms, along with the physiological and clinical implications of these changes.
成纤维细胞生长因子21（FGF21）被认为可改善肥胖人群有氧运动期间的新陈代谢。然而，运动干预的多样性导致该领域存在差异。因此，我们旨在系统回顾关于有氧运动对超重和肥胖人群FGF21影响的现有文献。我们的检索包括在PubMed、Science Direct和Medline上找到的2009年至2021年11月期间发表的原始文章。纳入临床和临床前研究。排除受试者或动物患有其他疾病（如癌症、中风）的研究。从最初的43项研究中，19项（临床研究=9项；临床前研究=10项）符合纳入本综述的条件。主要研究结果是，急性运动往往会增加循环中FGF21的水平。相比之下，长期运动计划（≥4周）则产生相反的效果，同时会诱导脂肪组织、肝脏和骨骼肌中FGF受体和β-klotho的mRNA和蛋白质增加。总之，临床和临床前研究均表明，有氧运动可使循环和组织中的FGF21及其受体和共受体发生变化。未来需要开展研究以阐明这些变化的机制及其生理和临床意义。
