可见光诱导的钯催化1,3 - 二烯与溴二氟乙酰胺的1,4 - 双官能化反应
Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides.
作者信息
Liu Zhi-Lin, Ye Zhi-Peng, Chen Yi-Xuan, Zheng Yu, Xie Zhen-Zhen, Guan Jian-Ping, Xiao Jun-An, Chen Kai, Xiang Hao-Yue, Yang Hua
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China.
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530001, Guangxi, P. R. China.
出版信息
Org Lett. 2022 Jan 28;24(3):924-928. doi: 10.1021/acs.orglett.1c04293. Epub 2022 Jan 18.
A highly modular 1,4-difunctionalization of 1,3-dienes with bromodifluoroacetamides and sulfinates/amines through a photoinduced palladium-catalyzed radical relay process is described herein. This developed protocol offers a facile and general route to access a variety of value-added CF-incorporated alkenes in moderate to good yields. The versatility and flexibility of this approach have been well illustrated by readily accessible starting materials, synthetic convenience, and wide functional group compatibility.
本文描述了一种通过光致钯催化自由基接力过程，实现1,3-二烯与溴二氟乙酰胺和亚磺酸盐/胺的高度模块化1,4-双官能化反应。这一开发的方案提供了一种简便通用的方法，能够以中等到良好的产率获得各种含CF的增值烯烃。这种方法的多功能性和灵活性通过易于获得的起始原料、合成便利性以及广泛的官能团兼容性得到了充分体现。
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