From the Department of Internal Medicine.
Pancreas. 2021;50(10):1440-1444. doi: 10.1097/MPA.0000000000001952.
The aim of this study was to determine if hypophosphatemia is more common in patients with severe alcohol-induced acute pancreatitis (AAP).
This is a retrospective, single institution, cohort study that analyzed 147 patients admitted to the hospital for AAP. Multivariate logistic regression was used to determine if hypophosphatemia would be related to clinical outcomes of disease severity.
Hypophosphatemia was more common in patients with severe AAP at admission; in addition, all patients with severe AAP (100%) eventually developed hypophosphatemia during admission, relative to those with mild (43%) and moderately severe (54%) AAP. The magnitude of the lowest phosphate measurement obtained during admission was lower in patients with severe AAP (mean, 1.5 mg/dL, standard deviation [SD], 0.5 mg/dL) relative to those with mild (mean, 2.6 mg/dL; SD, 0.9 mg/dL) and moderately severe (mean, 2.3 mg/dL; SD, 0.9 mg/dL) AAP (P < 0.001). Finally, patients who developed hypophosphatemia during admission were more likely to require intensive care unit admission (P < 0.001), vasopressors (P = 0.01), or intubation (P = 0.003).
Hypophosphatemia is more common and of greater magnitude in patients admitted to the hospital with severe AAP. In addition, patients with severe AAP who develop hypophosphatemia during admission are more likely to have poorer clinical outcomes.
本研究旨在确定低磷血症是否更常见于严重酒精性急性胰腺炎（AAP）患者。
这是一项回顾性、单中心队列研究，分析了 147 例因 AAP 住院的患者。多变量逻辑回归用于确定低磷血症是否与疾病严重程度的临床结局相关。
入院时严重 AAP 患者更易发生低磷血症；此外，所有严重 AAP 患者（100%）在住院期间最终均发生低磷血症，而轻度（43%）和中度严重（54%）AAP 患者则无此情况。入院时获得的最低磷测量值在严重 AAP 患者中较低（均值 1.5mg/dL，标准差 0.5mg/dL），而在轻度（均值 2.6mg/dL；标准差 0.9mg/dL）和中度严重（均值 2.3mg/dL；标准差 0.9mg/dL）AAP 患者中则较高（P<0.001）。最后，住院期间发生低磷血症的患者更有可能需要入住重症监护病房（P<0.001）、使用血管加压素（P=0.01）或插管（P=0.003）。
入院时患有严重 AAP 的患者更易发生且程度更严重的低磷血症。此外，在住院期间发生低磷血症的严重 AAP 患者更可能出现较差的临床结局。
