Ventura G J, Drewinko B, Keating M J
Department of Hematology, University of Texas System Cancer Center, Houston 77030.
Hematol Pathol. 1987;1(2):113-6.
Patterns of recovery for peripheral blood neutrophils and platelets were analyzed in 65 patients with acute myeloblastic leukemia (AML) undergoing their first course of induction chemotherapy. Specifically, for every patient linear correlation coefficients (r values) were computed for neutrophils versus platelet counts every three days from Day 12 to 27 of therapy. Correlations were designated as "significant" if r greater than or equal to 0.82 (p less than or equal to 0.05). Patients who would enter complete remission with the first course of therapy were significantly more likely to have significant neutrophil-platelet correlations in the recovery phase than patients who did not achieve remission with the first course or who would have resistant disease (76% versus 20% and 76% versus 15%, respectively, both p less than 0.001). Although these data are preliminary and retrospective they nonetheless demonstrate a trend that may prove useful for patient monitoring if proven correct by formal studies. A prospective investigation examining neutrophil and platelet correlations within a defined period of early hematologic recovery is indicated to assess if such parameters have early prognostic value for the prediction of remission in individual patients receiving induction therapy for AML.
对65例接受首个疗程诱导化疗的急性髓细胞白血病（AML）患者外周血中性粒细胞和血小板的恢复模式进行了分析。具体而言，对于每例患者，在治疗的第12天至27天期间，每三天计算一次中性粒细胞与血小板计数的线性相关系数（r值）。如果r大于或等于0.82（p小于或等于0.05），则相关性被指定为“显著”。与首个疗程未达到缓解或患有难治性疾病的患者相比，首个疗程治疗后进入完全缓解的患者在恢复阶段中性粒细胞与血小板显著相关的可能性明显更高（分别为76%对20%和76%对15%，p均小于0.001）。尽管这些数据是初步的且为回顾性的，但它们仍显示出一种趋势，如果经正式研究证实正确，可能对患者监测有用。需要进行一项前瞻性研究，在早期血液学恢复的特定时间段内检查中性粒细胞和血小板的相关性，以评估这些参数是否对接受AML诱导治疗的个体患者的缓解预测具有早期预后价值。
