Saito Tatsushi, Karasawa Hideaki, Hatsuzawa Yuri, Kobayashi Minoru, Kajiwara Taiki, Suzuki Hideyuki, Kohyama Atsushi, Watanabe Kazuhiro, Kamei Takashi, Ohnuma Shinobu, Unno Michiaki
Dept. of Surgery, Tohoku University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2021 Dec;48(13):1625-1627.
A 70's woman complaining blood stool and lower abdominal pain visited a local doctor and was given the diagnosis of rectal cancer by colonoscopy. CT, MRI, and bone scintigraphy revealed multiple lymph node and bone metastasis and peritoneal dissemination. She had developed disseminated intravascular coagulation(DIC)during hospitalization, and the cause was considered to be disseminated carcinomatosis of the bone marrow. Thus, we emergently started chemotherapy with mFOLFOX6, in conjunction with anticoagulation therapy, and the DIC was resolved 11 days after the introduction. Partial response was achieved and the chemotherapy has been continued after 5 months from the onset of the DIC. Since the prognosis of solid tumor patients who developed DIC has been reported to be extremely poor, prompt introduction of chemotherapy should be considered.
