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食用黎豆（黎豆 Mucuna pruriences (L.) DC. var. utilis）可改善 3×Tg-AD 小鼠的认知功能和神经病理学。

Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice.

机构信息

Department of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama, 350-0288, Japan.

Department of International Food and Agricultural Science, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan.

出版信息

Sci Rep. 2022 Jan 19;12(1):996. doi: 10.1038/s41598-022-04777-z.

DOI:10.1038/s41598-022-04777-z
PMID:35046433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8770455/
Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangles (NFTs). Mucuna beans (Mucuna pruriences (L.) DC. var. utilis) are unique plants containing 3-9% L-3,4-dihydroxyphenylalanine (L-DOPA). Here we investigated the effect of the administration of Mucuna beans on AD prevention by feeding triple-transgenic mice (3 × Tg-AD mice) with a diet containing Mucuna beans for 13 months. The levels of Aβ oligomers and detergent-insoluble phosphorylated tau decreased in the brain of mice fed with Mucuna beans (Mucuna group) compared to those of the Control group. Aβ accumulation and phosphorylated tau accumulation in the brain in the Mucuna group were also reduced. In addition, administration of Mucuna beans improved cognitive function. These results suggest that administration of Mucuna beans may have a preventive effect on AD development in 3 × Tg-AD mice.

摘要

阿尔茨海默病（AD）是一种神经退行性疾病，其特征是细胞外淀粉样β肽（Aβ）的积累导致老年斑和细胞内过度磷酸化的tau 蛋白导致神经原纤维缠结（NFTs）。木豆（Mucuna pruriences（L.）DC. var. utilis）是一种独特的植物，含有 3-9%的 L-3,4-二羟基苯丙氨酸（L-DOPA）。在这里，我们通过用含有木豆的饮食喂养三转基因小鼠（3×Tg-AD 小鼠）13 个月来研究木豆给药对 AD 预防的影响。与对照组相比，喂食木豆的小鼠（木豆组）大脑中的 Aβ 寡聚物和去污剂不溶性磷酸化 tau 水平降低。木豆组大脑中的 Aβ 积累和磷酸化 tau 积累也减少。此外，木豆的给药改善了认知功能。这些结果表明，木豆的给药可能对 3×Tg-AD 小鼠的 AD 发展具有预防作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f092/8770455/99d9b4f9e816/41598_2022_4777_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f092/8770455/99d9b4f9e816/41598_2022_4777_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f092/8770455/ca4920fed555/41598_2022_4777_Fig1_HTML.jpg
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