Deflers Hélène, Gandar Frédéric, Bolen Géraldine, Detilleux Johann, Sandersen Charlotte, Marlier Didier
Exotic Pet Department, Veterinary Clinic Alvetia, F57100 Thionville, France.
Diagnostic Imaging Section, Department of Clinical Sciences of Companion Animals and Equine, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, B4000 Liège, Belgium.
Vet Sci. 2022 Jan 14;9(1):28. doi: 10.3390/vetsci9010028.
The aim of this study was to evaluate and compare the effects of single doses of butorphanol, morphine, and tramadol on gastrointestinal motility in rabbits () using non-invasive imaging methods, such as radiographic barium follow through and ultrasonographic contraction counts. Time-lapse radiographic and ultrasound examinations were performed before and after a single intramuscular dose of 5 mg kg butorphanol, 10 mg kg morphine, or 10 mg kg tramadol. Pyloric and duodenal contraction counts by ultrasonography and radiographic repletion scores for the stomach and caecum were analysed using a mixed linear model. No significant effect was noted on ultrasound examinations of pyloric and duodenal contractions after administration of an opioid treatment. Morphine had a significant effect on the stomach and the caecum repletion scores, whereas butorphanol had a significant effect only on the caecum repletion score. Tramadol had no significant effect on the stomach or caecum repletion scores. The present findings suggest that a single dose of 5 mg kg butorphanol or 10 mg kg morphine temporarily slows gastrointestinal transit in healthy rabbits, preventing physiological progression of the alimentary bolus without the induction of ileus. In contrast, a single dose of 10 mg kg tramadol has no such effects.
本研究的目的是使用非侵入性成像方法，如放射造影钡剂追踪和超声收缩计数，评估和比较单次剂量的布托啡诺、吗啡和曲马多对兔胃肠道蠕动的影响。在单次肌肉注射5mg/kg布托啡诺、10mg/kg吗啡或10mg/kg曲马多之前和之后进行延时放射造影和超声检查。使用混合线性模型分析通过超声检查得到的幽门和十二指肠收缩计数以及胃和盲肠的放射造影充盈评分。给予阿片类药物治疗后，在幽门和十二指肠收缩的超声检查中未发现显著影响。吗啡对胃和盲肠充盈评分有显著影响，而布托啡诺仅对盲肠充盈评分有显著影响。曲马多对胃或盲肠充盈评分无显著影响。目前的研究结果表明，单次剂量的5mg/kg布托啡诺或10mg/kg吗啡会暂时减缓健康兔的胃肠道转运，阻止食团的生理推进而不诱发肠梗阻。相比之下，单次剂量的10mg/kg曲马多没有此类作用。
