Department for Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Norwegian Research Centre for Women's Health, Women and Children's Division, Oslo University Hospital, Oslo, Norway.
Nord J Psychiatry. 2022 Aug;76(6):423-432. doi: 10.1080/08039488.2021.1998616. Epub 2022 Jan 20.
Perinatal mental health disorders affect a significant number of women with debilitating and potentially life-threatening consequences. Researchers in Nordic countries have access to high quality, population-based data sources and the possibility to link data, and are thus uniquely positioned to fill current evidence gaps. We aimed to review how Nordic studies have contributed to existing evidence on perinatal mental health.
We summarized examples of published evidence on perinatal mental health derived from large population-based longitudinal and register-based data from Denmark, Finland, Iceland, Norway and Sweden.
Nordic datasets, such as the Danish National Birth Cohort, the FinnBrain Birth Cohort Study, the Icelandic SAGA cohort, the Norwegian MoBa and ABC studies, as well as the Swedish BASIC and Mom2B studies facilitate the study of prevalence of perinatal mental disorders, and further provide opportunity to prospectively test etiological hypotheses, yielding comprehensive suggestions about the underlying causal mechanisms. The large sample size, extensive follow-up, multiple measurement points, large geographic coverage, biological sampling and the possibility to link data to national registries renders them unique. The use of novel approaches, such as the digital phenotyping data in the novel application-based Mom2B cohort recording even voice qualities and digital phenotyping, or the Danish study design paralleling a natural experiment are considered strengths of such research.
Nordic data sources have contributed substantially to the existing evidence, and can guide future work focused on the study of background, genetic and environmental factors to ultimately define vulnerable groups at risk for psychiatric disorders following childbirth.
围产期精神健康障碍影响着大量女性，给她们带来了衰弱甚至可能危及生命的后果。北欧国家的研究人员拥有高质量的基于人群的数据源和数据链接的可能性，因此他们在填补当前证据空白方面具有独特的优势。我们旨在回顾北欧研究在围产期心理健康方面的现有证据做出了哪些贡献。
我们总结了来自丹麦、芬兰、冰岛、挪威和瑞典的大型基于人群的纵向和基于登记的数据集，对围产期心理健康的已发表证据进行了举例说明。
北欧数据集，如丹麦国家出生队列、芬兰脑出生队列研究、冰岛 SAGA 队列、挪威 MoBa 和 ABC 研究，以及瑞典 BASIC 和 Mom2B 研究，促进了围产期精神障碍的患病率研究，并进一步提供了前瞻性检验病因假设的机会，对潜在的因果机制提出了全面的建议。这些研究的优势在于其大规模的样本量、广泛的随访、多个测量点、广泛的地理覆盖范围、生物样本采集以及与国家登记处链接数据的可能性。新颖的方法的应用，如基于应用程序的 Mom2B 队列中记录甚至声音质量和数字表型的数字表型数据，或者丹麦的研究设计模拟自然实验，也被认为是此类研究的优势。
北欧数据源对现有证据做出了重大贡献，并可以指导未来的工作，重点研究围产期精神障碍的背景、遗传和环境因素，最终确定分娩后易患精神疾病的脆弱群体。
