鉴定基于 ACK1/TNK2 的结肠癌预后标志物，预测生存和炎症特征。
Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes.
机构信息
State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China.
Department of Immunology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China.
出版信息
BMC Cancer. 2022 Jan 20;22(1):84. doi: 10.1186/s12885-021-09165-w.
Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it is likely to become a potential target for cancer treatment. We found that the expression of the ACK1 gene in colon cancer was higher than that in normal tissues adjacent to cancer, and high expression of the ACK1 gene was associated with poor prognosis of patients. We assessed the prognosis of colon cancer based on ACK1-related genes and constructed a model that can predict the prognosis of colon cancer patients in colon cancer data from The Cancer Genome Atlas (TCGA) database. We then explored the relationship between ACK1 and the immune microenvironment of colon cancer. The overexpression of ACK1 might hinder the function of antigen-presenting cells. The colon cancer prognosis prediction model we constructed has certain significance for clinicians to judge the prognosis of patients with colon cancer. The expression of the ACK1 gene might affect the infiltration level of a variety of immune cells and immunomodulators in the immune microenvironment.
激活的 Cdc42 相关激酶 1（ACK1）是一种酪氨酸激酶，在许多癌症中被认为是一种癌基因，可能成为癌症治疗的潜在靶点。我们发现 ACK1 基因在结肠癌中的表达高于癌旁正常组织，ACK1 基因的高表达与患者预后不良相关。我们基于 ACK1 相关基因评估结肠癌的预后，并构建了一个可以预测 TCGA 数据库中结肠癌患者预后的模型。然后，我们探讨了 ACK1 与结肠癌免疫微环境的关系。ACK1 的过表达可能会阻碍抗原呈递细胞的功能。我们构建的结肠癌预后预测模型对临床医生判断结肠癌患者的预后具有一定的意义。ACK1 基因的表达可能会影响免疫微环境中多种免疫细胞和免疫调节剂的浸润水平。
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