Department of Gastrointestinal Surgery, The First affiliated hospital of Zhengzhou University, Zhengzhou, China.
Pharmacy Intravenous Admixture Services, The First affiliated hospital of Zhengzhou University, Zhengzhou, China.
Scand J Immunol. 2022 Feb;95(2):e13119. doi: 10.1111/sji.13119. Epub 2021 Dec 26.
The incidence of colon cancer is amongst the top three in the world. The tumour microenvironment plays an important role in the occurrence and development of colon cancer. Stromal cells and immune cells are the main components of the tumour microenvironment. Our study detected genes, which affected the infiltration of stromal, immune cells and the way they affected the prognosis of colon cancer patients. We found that the colon's immune system had a special way to affect the tumour microenvironment. Moderate infiltration of stromal and immune cells was proved to be important protective factors for colon cancer patients, which has not been found in other tumours. C3, C5, CXCL12, GNAI1, LPAR1, PENK, PYY, SAA1 and SST were the differential expression hub genes of moderate-stromal and immune score group. They had a more significant correlation with tumour purity and infiltration of B cells, CD8 T cells, CD4 T cells, macrophage, neutrophil, democratic cells. The proteins encoded by C3, C5, CXCL12, GNAI1, PENK, PYY, SST were detected in colon cancer cells. These genes had the potential to become markers to predict the prognosis of patients with colon cancer.
结肠癌的发病率位居世界前三。肿瘤微环境在结肠癌的发生发展中起着重要作用。间质细胞和免疫细胞是肿瘤微环境的主要组成部分。我们的研究检测了影响间质、免疫细胞浸润的基因，以及它们影响结肠癌患者预后的方式。我们发现，结肠的免疫系统有一种特殊的方式来影响肿瘤微环境。适度浸润的间质和免疫细胞被证明是结肠癌患者的重要保护因素，这在其他肿瘤中尚未发现。C3、C5、CXCL12、GNAI1、LPAR1、PENK、PYY、SAA1 和 SST 是中等程度的间质和免疫评分组的差异表达枢纽基因。它们与肿瘤纯度以及 B 细胞、CD8 T 细胞、CD4 T 细胞、巨噬细胞、中性粒细胞、树突状细胞浸润的相关性更显著。C3、C5、CXCL12、GNAI1、PENK、PYY、SST 编码的蛋白质在结肠癌细胞中被检测到。这些基因有可能成为预测结肠癌患者预后的标志物。
