Régnier B, Safran D, Carlet J, Simoneau G, Rapin M
Ann Anesthesiol Fr. 1978;19(10):859-62.
This work aims at the evaluation of the effects of dobutamine in the effects of dobutamine in the treatment of septic shock and to compare them to the effects of dopamine used in the same conditions. Eleven patients presenting with both a state of septic shock and confirmed cardiac insufficiency were submitted to the protocol. The dosage was determined by the clinical results : 6.22 microgram/kg/min for dopamine and 4.2 to 25 microgram/kg/min for dobutamine. The results show that although the effect on cardiac output is comparable with the two drugs, some differences in their effects delineates their respective distinct indications. Indeed, although dobutamine seems less arythmic, lovers more the ventricular filling pressure and increases less the intra-pulmonary shunt, dopamine causes less reduction in the systemic resistance which in the case of septic shock seems more logical. Nevertheless dobutamine is perhaps easier to handle.
这项工作旨在评估多巴酚丁胺在治疗感染性休克中的作用，并将其与在相同情况下使用的多巴胺的作用进行比较。11例同时患有感染性休克和确诊心脏功能不全的患者接受了该方案治疗。剂量根据临床结果确定：多巴胺为6.22微克/千克/分钟，多巴酚丁胺为4.2至25微克/千克/分钟。结果表明，尽管两种药物对心输出量的影响相当，但它们作用上的一些差异明确了各自不同的适应症。事实上，尽管多巴酚丁胺似乎较少引起心律失常，能更好地维持心室充盈压且较少增加肺内分流，但多巴胺引起的全身阻力降低较少，这在感染性休克的情况下似乎更合理。然而，多巴酚丁胺可能更容易操作。
