Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.
Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
J Cell Biol. 2022 Feb 7;221(2). doi: 10.1083/jcb.202112087. Epub 2022 Jan 21.
WASP is a remodeler of the actin cytoskeleton, but its mechanistic contribution to neutrophil migration is unclear. In this issue, Brunetti et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202104046) show that WASP is recruited to substrate-induced membrane deformations near the cell front, where it induces Arp2/3 complex-mediated local actin assembly to direct migration.
WASP 是肌动蛋白细胞骨架的重塑因子，但它对中性粒细胞迁移的机械贡献尚不清楚。在本期杂志中，Brunetti 等人（2021.《细胞生物学杂志》https://doi.org/10.1083/jcb.202104046）表明，WASP 被招募到细胞前缘附近由底物诱导的膜变形处，在该处它诱导 Arp2/3 复合物介导的局部肌动蛋白组装来指导迁移。
