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乙状窦后入路至桥小脑角后的功能预后:来自一个超过13年单中心经验的观察结果

Functional outcomes after retrosigmoid approach to the cerebellopontine angle: Observations from a single-center experience of over 13 years.

作者信息

Aftahy Amir Kaywan, Goldberg Maria, Butenschoen Vicki M, Wagner Arthur, Meyer Bernhard, Negwer Chiara

机构信息

Technical University Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurosurgery, Munich, Germany.

出版信息

Brain Spine. 2024 Aug 8;4:102909. doi: 10.1016/j.bas.2024.102909. eCollection 2024.

Abstract

INTRODUCTION

Accessing the posterior base of the skull is complex because of the vital neurovascular structures in the area. However, the retrosigmoid approach (RSA) offers a solution to this challenge.

RESEARCH QUESTION

To analyze surgical outcome of RSA.

MATERIAL AND METHODS

This study involved a retrospective review of patient charts from a single center, focusing on the surgical procedure and outcomes following the operation.

RESULTS

The study included 517 patients suffering from conditions like vestibular schwannomas (VS), metastatic cancers, and trigeminal neuralgia. The most frequent symptoms reported were balance disorders (42.7%), hearing loss (36.5%), walking difficulties (21.2%), headaches (18.9%), facial pain (17.1%), issues with trigeminal nerve function (14.1%), cerebellar dysfunction (13.5%), and facial nerve paralysis (10.2%). The rate of complications stood at 21.1%, with 11.3% of patients needing revision surgery. The median score on the Clavien-Dindo scale was 2, and the rate of mortality related to surgery was 1.0%. Permanent symptom improvement was seen in 72.1% of cases. Temporary new deficits occurred in 43.2% of patients, with facial nerve paralysis being the most common (14.1%). No significant correlation was found between the size of the craniotomy and the extent of tumor resection (p = 0.155), except in the case of VS (p = 0.041). Larger craniotomy sizes were associated with higher rates of complications (p = 0.016), especially CSF leaks (p = 0.006). Complications significantly affected the likelihood and number of new deficits (p < 0.001 for both), particularly postoperative bleeding (p = 0.019, p = 0.001), CSF leaks (p = 0.026, p = 0.039), and hydrocephalus (p = 0.050, p = 0.007).

CONCLUSIONS

The potential for complications related to the surgical approach cannot be overlooked. The size of the tumor should not dictate larger surgical approaches due to the associated increase in postoperative complications; a tailored approach that considers the precise tumor location and pathology is crucial for optimizing postoperative outcomes.

摘要

引言

由于该区域存在重要的神经血管结构,进入颅后窝底部较为复杂。然而,乙状窦后入路(RSA)为这一挑战提供了解决方案。

研究问题

分析乙状窦后入路的手术效果。

材料与方法

本研究对来自单一中心的患者病历进行回顾性分析,重点关注手术过程及术后结果。

结果

该研究纳入了517例患有前庭神经鞘瘤(VS)、转移性癌症和三叉神经痛等疾病的患者。报告的最常见症状为平衡障碍(42.7%)、听力丧失(36.5%)、行走困难(21.2%)、头痛(18.9%)、面部疼痛(17.1%)、三叉神经功能问题(14.1%)、小脑功能障碍(13.5%)和面神经麻痹(10.2%)。并发症发生率为21.1%,11.3%的患者需要进行翻修手术。Clavien-Dindo量表的中位数评分为2,手术相关死亡率为1.0%。72.1%的病例出现永久性症状改善。43.2%的患者出现暂时性新的功能缺损,其中面神经麻痹最为常见(14.1%)。除VS病例外(p = 0.041),开颅大小与肿瘤切除范围之间未发现显著相关性(p = 0.155)。较大的开颅大小与较高的并发症发生率相关(p = 0.016),尤其是脑脊液漏(p = 0.006)。并发症显著影响新功能缺损的可能性和数量(两者p < 0.001),尤其是术后出血(p = 0.019,p = 0.001)、脑脊液漏(p = 0.026,p = 0.039)和脑积水(p = 0.050,p = 0.007)。

结论

不能忽视与手术入路相关的并发症风险。由于术后并发症会相应增加,肿瘤大小不应决定采用更大的手术入路;考虑肿瘤精确位置和病理情况的个体化方法对于优化术后结果至关重要。

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