直肠胃肠道间质瘤局部切除与根治性切除的生存结局：SEER 数据库分析。
Survival outcome of local vs. radical excision in rectal gastrointestinal stromal tumor: a SEER database analysis.
机构信息
The First Affiliated Hospital, Jinan University, Guangzhou, China.
Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, China.
出版信息
BMC Surg. 2022 Jan 22;22(1):21. doi: 10.1186/s12893-022-01485-3.
BACKGROUND
The choice of surgical strategy for patients with rectal gastrointestinal stromal tumor (GIST) remains controversial. This study aims to address whether the surgical procedure [local excision (LE) vs. radical excision (RE)] influences the survival outcomes.
METHODS
The information of the patients recruited in this study was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. A survival curve was used to evaluate the differences in cancer-specific survival (CSS).
RESULTS
No significant difference was detected in the CSS between the LE and RE groups. Also, no significant differences were observed in the CSS between the two groups with respect to different T classification, N classification, tumor differentiation, tumor size, regional LN surgery, age, gender, race, chemotherapy, and radiotherapy. The T classification and age were independent prognostic factors in rectal GIST patients.
CONCLUSIONS
LE and RE have similar survival time after surgery, and LE could be considered as an effective surgical approach for rectal GIST.
背景
直肠胃肠道间质瘤（GIST）患者的手术策略选择仍存在争议。本研究旨在探讨手术方式（局部切除[LE]与根治性切除[RE]）是否影响生存结局。
方法
本研究的患者信息来自监测、流行病学和最终结果（SEER）数据库。采用生存曲线评估癌症特异性生存（CSS）的差异。
结果
LE 组和 RE 组的 CSS 无显著差异。此外，两组之间在不同 T 分级、N 分级、肿瘤分化、肿瘤大小、区域淋巴结手术、年龄、性别、种族、化疗和放疗方面的 CSS 也无显著差异。T 分级和年龄是直肠 GIST 患者的独立预后因素。
结论
LE 和 RE 术后的生存时间相似，LE 可被视为直肠 GIST 的有效手术方法。
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