Chang C-Y, Lin M-H, Kuo C-C, Lu C-H, Wu D-M, Tsai M-K, Chu N-F
Prof. Nain-Feng Chu, PO Box 90048-509, Nei-Hu, Taipei, Taiwan, ROC, E-mail:
J Nutr Health Aging. 2022;26(1):6-12. doi: 10.1007/s12603-021-1714-3.
Frailty is a significant public health and clinical issue among the elder population. This study aimed to evaluate the nutritional status and renal function in relation to frailty among elderly Taiwanese.
We administered community-based health surveys to the elder population in Chiayi County, Taiwan, from 2017 to 2019.
We measured nutritional status (including serum albumin and total protein levels), renal function (including serum blood urea nitrogen, creatinine, urine protein, and urine creatinine levels), hand grip strength (GS) and calculated appendicular muscle mass (AMM).
The study recruited 3739 participants (2139 women). Participants of both sexes with normal GS had higher serum albumin levels and lower urine protein/creatinine ratios (UPCRs). For the men with normal and weak GS, serum albumin levels were 4.15 ± 0.2 and 4.10 ± 0.2 g/dL (p < 0.01), and UPCRs were 123.1 ± 219.6 and 188.7 ± 366.2 (p < 0.001), respectively. GS was positively correlated with serum albumin and urine creatinine levels (r = 0.136 and 0.177, both p < 0.001). AMM was also positively correlated with serum albumin and urine creatinine levels (r = 0.078 and 0.091, both p < 0.001). In the multivariate regression model, for every 1 g/dL increase in serum albumin level, there was a 1.9 and 1.7-kg increase in GS for men and women (p < 0.05 and p < 0.01), respectively. The final model for predicting GS included age, albumin, BUN, and UPCR (urine creatinine for women) which presented a variance of 22.1% and 13.8%, respectively.
Proper dietary nutritional intake and maintaining renal function are key elements for preventing frailty among elder population in Taiwan.
衰弱是老年人群中一个重要的公共卫生和临床问题。本研究旨在评估台湾老年人中与衰弱相关的营养状况和肾功能。
我们于2017年至2019年对台湾嘉义县的老年人群进行了基于社区的健康调查。
我们测量了营养状况（包括血清白蛋白和总蛋白水平）、肾功能（包括血清血尿素氮、肌酐、尿蛋白和尿肌酐水平）、握力（GS）并计算了四肢肌肉质量（AMM）。
该研究招募了3739名参与者（2139名女性）。握力正常的男女参与者血清白蛋白水平较高，尿蛋白/肌酐比值（UPCR）较低。对于握力正常和较弱的男性，血清白蛋白水平分别为4.15±0.2和4.10±0.2 g/dL（p<0.01），UPCR分别为123.1±219.6和188.7±366.2（p<0.001）。握力与血清白蛋白和尿肌酐水平呈正相关（r=0.136和0.177，均p<0.001）。四肢肌肉质量也与血清白蛋白和尿肌酐水平呈正相关（r=0.078和0.091，均p<0.001）。在多变量回归模型中，血清白蛋白水平每增加1 g/dL，男性和女性的握力分别增加1.9和1.7 kg（p<0.05和p<0.01）。预测握力的最终模型包括年龄、白蛋白、血尿素氮和UPCR（女性为尿肌酐），其方差分别为22.1%和13.8%。
适当的饮食营养摄入和维持肾功能是预防台湾老年人群衰弱的关键因素。
