Horellou M F, Feiss P, Voultoury J C, Gay R
Ann Anesthesiol Fr. 1978;19(11-12):941-6.
One case of Phenindione (PID) adverse reaction is reported. The patient showed a typical picture of immunological reaction to the drug. In spite of severe bacteremia, she recovered. Only 33 cases of PID intolerance are reported in the literature. In all these patients, renal failure occurred. Superinfection is the most frequent cause of death. PID adverse reaction should be evoqued in the presence of signs such a fever, asthenia, anorexia and cutaneous reaction. The PID should be stopped immediatly but renal failure yet develops. During a PID treatment, frequent evaluation of blood azotemia, creatinine and proteinuria should be performed.
报告了1例苯茚二酮（PID）不良反应病例。该患者表现出对该药物典型的免疫反应症状。尽管发生了严重菌血症，但她仍康复了。文献中仅报道了33例PID不耐受病例。在所有这些患者中，均出现了肾衰竭。二重感染是最常见的死亡原因。当出现发热、乏力、厌食和皮肤反应等症状时，应考虑PID不良反应。应立即停用PID，但肾衰竭仍会发生。在PID治疗期间，应频繁评估血氮质、肌酐和蛋白尿。
