Erden Semih, Nalbant Kevser, Kılınç İbrahim
Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
Department of Child and Adolescent Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Clin Psychopharmacol Neurosci. 2022 Feb 28;20(1):135-142. doi: 10.9758/cpn.2022.20.1.135.
To investigate the possible relationship between relaxin-3 and autism spectrum disorder (ASD).
Serum relaxin-3 was measured in 80 children (50 children diagnosed with ASD and 30 controls). Symptom severity in the ASD group was evaluated by the Childhood Autism Rating Scale (CARS). Behavioral and nutritional problems in the groups were evaluated using the Abnormal Behavior Checklist (ABC) and the Children's Eating Behavior Questionnaire (CEBQ).
Our findings showed that serum relaxin-3 levels were higher in children with ASD than in the controls. The listening response sub-scale score of the CARS scale was found to decrease as the level of relaxin-3 increased. However, as relaxin-3 levels increased in children with ASD, it was found that the speech problem sub-scale score on the ABC scale and the desire to drink score on the CEBQ scale increased, but the satiety responsiveness and food fussiness scores decreased.
This study the first to investigate serum levels of relaxin-3, which has a role in regulating social behavior and nutritional behavior in children with ASD.
探讨松弛素-3与自闭症谱系障碍（ASD）之间可能的关系。
对80名儿童（50名被诊断为ASD的儿童和30名对照儿童）测定血清松弛素-3。通过儿童自闭症评定量表（CARS）评估ASD组的症状严重程度。使用异常行为检查表（ABC）和儿童饮食行为问卷（CEBQ）评估两组的行为和营养问题。
我们的研究结果表明，ASD儿童的血清松弛素-3水平高于对照组。发现CARS量表的听力反应子量表得分随着松弛素-3水平的升高而降低。然而，随着ASD儿童松弛素-3水平的升高，发现ABC量表上的言语问题子量表得分和CEBQ量表上的饮水欲望得分增加，但饱腹感反应和食物挑剔得分降低。
本研究首次调查了松弛素-3的血清水平，其在调节ASD儿童的社交行为和营养行为方面具有作用。
