Klockars Anica, Levine Allen Stuart, Olszewski Pawel Karol
Department of Biological Sciences, University of Waikato , Hamilton , New Zealand.
Department of Food Science and Nutrition, University of Minnesota , St. Paul, MN , USA.
Front Endocrinol (Lausanne). 2015 Apr 28;6:65. doi: 10.3389/fendo.2015.00065. eCollection 2015.
Centrally acting oxytocin (OT) is known to terminate food consumption in response to excessive stomach distension, increase in salt loading, and presence of toxins. Hypothalamic-hindbrain OT pathways facilitate these aspects of OT-induced hypophagia. However, recent discoveries have implicated OT in modifications of feeding via reward circuits: OT has been found to differentially affect consumption of individual macronutrients in choice and no-choice paradigms. In this mini-review, we focus on presenting and interpreting evidence that defines OT as a key component of mechanisms that reduce eating for pleasure and shape macronutrient preferences. We also provide remarks on challenges in integrating the knowledge on physiological and pathophysiological states in which both OT activity and macronutrient preferences are affected.
中枢作用的催产素（OT）已知可响应胃部过度扩张、盐负荷增加和毒素存在而终止食物摄入。下丘脑-后脑OT通路促进了OT诱导的食欲减退的这些方面。然而，最近的发现表明OT通过奖赏回路参与进食调节：已发现OT在选择和非选择范式中对个体常量营养素的消耗有不同影响。在这篇小型综述中，我们着重展示和解释将OT定义为减少愉悦性进食和塑造常量营养素偏好机制的关键组成部分的证据。我们还对整合OT活性和常量营养素偏好均受影响的生理和病理生理状态的知识所面临的挑战发表了看法。
